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. 2017 Dec 22;8:2557. doi: 10.3389/fmicb.2017.02557

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Copyright © 2017 Papa, Meuren, Coelho, Lucas, Mustafá, Lemos Matassoli, Silveira, Frost, Pezzuto, Ribeiro, Tanuri, Nogueira, Campanati, Bozza, Paula Neto, Pimentel-Coelho, Figueiredo, Aguiar and Arruda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HBMECs are productively infected by ZIKV. (A) HBMECs were mock treated or infected with ZIKV_PE243 or ZIKV_MR766, at the indicated MOI. After 48 h, cells were stained with 4G2 antibody and analyzed by immunofluorescence. (B,C) HBMECs were infected with ZIKV_PE243 or ZIKV_MR766 (MOI 1), produced in C6/36 cells (B) or produced in Vero cells (C). After different time points, supernatants were harvested and viral RNA was measured by qRT-PCR. (D,E) HBMECs were infected with ZIKV_PE243 or ZIKV_MR766 (MOI 1), produced in C6/36 cells (D) or produced in Vero cells (E). After different time points, supernatants were harvested and infectious particles were titrated by plaque assay. Data are represented as mean ± SD of two independent experiments.