Table 1.
Comparison of Inflammatory cytokines, chemokines, and growth factors levels in supernatant from human brain microvascular endothelial cell line (HBMEC) after infection with Brazilian and African ZIKV strains (ZIKVPE243 and ZIKVMR766).
| Control | ZIKVPE243 (MOI 0.1) | ZIKVMR766 (MOI 0.1) | |||
|---|---|---|---|---|---|
| pg/mL | pg/mL | Fold change | pg/mL | Fold change | |
| IMFLAMMATORY CYTOKINES | |||||
| IL1β | 1.11 | 1.56 | 1.41 | 0.76 | 0.68 |
| IL1ra | 28.13 | 52.9 | 1.88 | 52.9 | 1.88 |
| IL2 | – | – | – | – | – |
| IL4 | 5.35 | 10.74 | 2.01 | 7.77 | 1.45 |
| IL5 | – | – | – | 0.52 | – |
| IL6 | 356.83 | 929.23 | 2.60 | 469.71 | 1.32 |
| IL9 | – | 2.09 | – | 4.76 | – |
| IL10 | 12.93 | 13.33 | 1.03 | 37.04 | 2.86 |
| IL12 | 62.97 | 68.49 | 1.09 | 197.02 | 3.13 |
| IL13 | 1.04 | 1.15 | 1.11 | 2.91 | 2.80 |
| IL15 | – | 1.49 | – | 0.37 | – |
| IL17a | 94.98 | 113.23 | 1.19 | 11.4 | 0.12 |
| IFNγ | 46.27 | 72.54 | 1.57 | 90.71 | 1.96 |
| TNFα | 7.04 | 13.27 | 1.88 | 10.16 | 1.44 |
| CHEMOKINES | |||||
| Eotaxin | 36.45 | 64.74 | 1.78 | 50.08 | 1.37 |
| IL8 | 225.15 | 674.93 | 3.00 | 583.62 | 2.59 |
| CXCL10 | 54.27 | 71.46 | 1.32 | 71.46 | 1.32 |
| CCL2 | 539.54 | 736.19 | 1.36 | 640.37 | 1.19 |
| CCL3 | 1.71 | 1.95 | 1.14 | 0.83 | 0.49 |
| CCL4 | 0.56 | 0.91 | 1.63 | 0.31 | 0.55 |
| CCL5 | 6.50 | 16.03 | 2.47 | 27.63 | 4.25 |
| GROWTH FACTORS | |||||
| Basic FGF | 97.97 | 116.48 | 1.19 | 21.2 | 0.22 |
| G-CSF | 3.29 | 13.04 | 3.96 | 6.53 | 1.98 |
| GM-CSF | – | – | – | – | – |
| IL7 | 10.43 | 11.35 | 1.09 | 21.36 | 2.05 |
| PDGF-BB | 137.21 | 364.5 | 2.66 | 149.3 | 1.09 |
| VEGF | 1111.64 | 1236.97 | 1.11 | 5505.51 | 4.95 |