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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Pharmacol Ther. 2017 Aug 23;181:169–182. doi: 10.1016/j.pharmthera.2017.08.011

Figure 2. Schematic of oxidative stress induced lung inflammation and role of IL-6 signaling pathways in conjunction with TLRs and NF-κB.

Figure 2

Oxidative stress leads to the generation of lipid peroxidation products, ROS, free radicals in lung cell types. These oxidants can further mediate activation of downstream biochemical events including increased and altered TLR expression and activation in response to allergens. Oxidants and oxidative stress also impart direct effect on NF-κB as well as on the molecules of NF-κB pathway leading to the production of inflammatory factors and lung damage. (Adapted and modified from (Mishra, et al., 2016)).