Table 1.
Serine threonine phosphatases of Leishmania major.a
| Family | L. major gene | Characterized Leishmania gene | Reference | |||
|---|---|---|---|---|---|---|
| STP | PPP | PP1 | LmjF.15.0220 | |||
| LmjF.28.0690 | ||||||
| LmjF.31.2630 LmjF.34.0780 |
||||||
| LmjF.34.0790 | ||||||
| LmjF.34.0800 LmjF.34.0810 LmjF.34.0850 |
||||||
| PP2A | LmjF.25.1320 LmjF.28.2670 |
|||||
| PP2B | LmjF.26.2530 LmjF.36.1980 |
|||||
| PP4 | LmjF.32.3040 | LdBPK_323230.1 | (111) | |||
| PP5 | LmjF.18.0150 | (112) | ||||
| PP6 | LmjF.34.4190 | |||||
| PP7 (PPEF) | LmjF.12.0660 | LinJ.12.0610 | (113, 114) | |||
| ApaH-like(ALPH) | LmjF.22.1600 LmjF.17.0580 |
|||||
| Shewanella-like | None | |||||
| kSTP (pseudo) | LmjF.05.0100 | |||||
| LmjF.09.0470 LmjF.12.0050 LmjF.13.1510 LmjF.13.1570 LmjF.22.1490 LmjF.24.0270 LmjF.26.2100 |
||||||
| LmjF.34.2770 | LinJ.34.2610 | (115) | ||||
| LmjF.36.2050 | ||||||
| LmjF.29.0440 LmjF.30.3280 |
||||||
| MPP (PP2C) | LmjF.14.0900 LmjF.15.0170 LmjF.36.0530 LmjF.32.1690 LmjF.27.2320 LmjF.36.1230 LmjF.30.0380 LmjF.25.2060 LmjF.06.0900 |
|||||
| LmjF.25.0750 | LinJ.25.0780 | (85, 116) | ||||
| LmjF.31.1320 | ||||||
| LmjF.34.2500 | LinJ.34.2310 | (114) | ||||
| LmjF.34.2510 | LinJ.34.2320 | (114) | ||||
| LmjF.27.1180 LmjF.34.0730 |
||||||
| FCP SCP |
LmjF.26.0160 LmjF.34.3920 LmjF.32.0100 LmjF.25.2030 LmjF.24.0290 LmjF.34.1250 LmjF.35.2620 LmjF.36.6780 LmjF.35.3520 LmjF.27.2180 LmjF.29.2400 LmjF.35.0190 LmjF.03.0890 |
|||||
aPhosphatases identified by mass spectrometry in the secretome of Leishmania parasites are marked in red (83–85, 92).
STP, serine threonine phosphatase; PPP, phosphoprotein phosphatase; MPP, metal-dependent phosphatase; FPP, F cell production phosphatase; SCP, small carboxy-terminal domain phosphatase; PP, protein phosphatase; PPEF, protein phosphatases with a E-helix/F-helix (EF)-hand (PPEF); kSTP, kinetoplastid specific STP.