Table 2.
Tyrosine phosphatases of Leishmania major.a
| Family | L. major gene | Charact. gene | Ref. | ||||
|---|---|---|---|---|---|---|---|
| PTP | Class I | Receptor | Nd | ||||
| Classical PTP | Non-receptor PTP | Eukaryotic like | LmjF36.5370 LmjF36.2180 |
LdBPK_365610.1 | (117) | ||
| Kinetosplastid | LmjF32.0640 | ||||||
| eDUSP PRL | LmjF16.0230 | (118) | |||||
| LmjF16.0250 | |||||||
| eDUSP CDC14 | LmjF09.0420 | ||||||
| Atypical DUSP | LRR-DUSP | LmjF28.0170 | |||||
| Kinatase | LmjF34.2190 | ||||||
| ANK-DUSP | Nd | ||||||
| STYX | LmjF21.0700 | ||||||
| MKP-like | LmjF27.1840 | ||||||
| Lipid-like phosphatases | LmjF04.0560 LmjF25.0570 LmjF33.2840 |
||||||
| LmjF22.0250 | (119) | ||||||
| DUSP | PTEN | Eukaryotic-like | LmjF34.1430 | ||||
| Kinetosplastid | LmjF25.0230 | ||||||
| MTM | LmjF20.1480 LmjF12.0320 |
||||||
| Kinetoplastid DUSP | LmjF03.0510 LmjF05.0220 LmjF08.0100 LmjF09.0550 LmjF13.0770 LmjF27.2210 LmjF28.0790 LmjF35.4650 LmjF32.1010 LmjF04.0840 LmjF05.0720 |
||||||
| MAKP phosphatase | Nd | ||||||
| Slingshot | Nd | ||||||
| Class II | LMPTP/ArsC reductase | LmjF01.0200 | |||||
| Class III | CDC25/ACR2 reductase | LmjF32.2740 | (120–123) | ||||
| Class IV | Asparate based PTP EyA | Nd | |||||
aPhosphatases identified by mass spectrometry in the secretome of Leishmania parasites are marked in red (83–85, 92).
PTP, protein tyrosine phosphatase; DUSP, dual specificity phosphatase; PRL, phosphatase of the regenerating liver; STYX, inactive STYX pseudo-phosphatase; MKP, mitogen activated protein kinase phosphatase; PTEN, phosphatase and tensin homologs; MTM, myotubularin; LMPTP, low-molecular -weight PTP; ArsC red/ACR2, arsenate reductase.