Table 1.
Characterization of gold nanoparticle-based constructs used in this study.
| Name | Diameter by number, nmb | Zeta potential, mV | AuNP core diameter by TEM, nm | ODN bound to AuNP (% of added) c | ODN/AuNP ratio mol/particle |
|---|---|---|---|---|---|
| AuNPa | 11.9 | -21.7 | 13.5 ± 1.5 | - | - |
| AuNP-NUAP | - | - | 2.5 | 224 | |
| AuNP-CTAP | 71.4 | -26.8 | 10.3 | 84 | |
| AuNP-STAT3d | 2.9 | -12.9 | 46.1 | 101 | |
| AuNP-COTRd | 49.4 | -28.7 | 27.7 | 74 | |
| AuNP-NUAP-STAT3d | 18.2 | -26.8 | 17.3 ± 1.4 | 8.2 | NUAP: 49 STAT3d: 60 |
| AuNP-CTAP-STAT3d | 52.4 | -29.5 | 16.3 | CTAP: 38 STAT3d: 60 |
a) AuNP were synthesized as described in 24; b) hydrodynamic diameters (number average); c) a ratio of [bound ODN]/ [added ODN]*100.