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. 2018 Jan 1;2(1):70–86. doi: 10.7150/ntno.21638

Figure 7.

Figure 7

(i) Images of the in-vivo study. The 9L bearing rats were treated with intraperitoneal administration of ganciclovir twice a day beginning on day 4 and then treated with a single infusion of PBAE/HSV-tk nanoparticles on day 6 (ii) Local brain delivery of PBAE/GFP nanoparticle leads to effective tumor transfection in-vivo. (iii) PBAE/HSVtk nanoparticles and ganciclovir (GCV) extend survival in a 9L gliosarcoma model. Reproduced with permission from Scheme 1, Figures 5 and 6 in ref. 113. © American Chemical Society (2015).