Figure 1.

Treatment with MR16-1 did not change blood pressure or body weight in both IκBNS^−/−/LDLr^−/− and LDLr^−/− mice. Both mice were received injection of phosphate-buffered saline (PBS) or MR16-1 (2 mg) once a week during a high-fat diet consumption of 16 weeks. Systolic blood pressure (A) and body weight (B) were similar among four groups. IκBNS/LDLr KO PBS: PBS-treated IκBNS^−/−/LDLr^−/− mice, LDLr KO PBS: PBS-treated LDLr^−/− mice. IκBNS/LDLr KO MR16-1: MR16-1-treated IκBNS^−/−/LDLr^−/− mice, LDLr KO MR16-1: MR16-1-treated LDLr^−/− mice. Data are expressed as mean ± SEM. NS, not significant.