Figure 3.

Simulation of oscillatory stimulation: spatiotemporal organization of intercellular [Ca²⁺]_c waves in islets. (A) Computed [Ca²⁺]_c responses of four typical cells during oscillatory glucose stimulation (upper panel) and binarized dynamics of all cells in the network (lower panel). The gray areas denote the stimulatory pulses realized by periodic increases of glucokinase reaction rates. (B) Space-time clusters of [Ca²⁺]_i activity during the four 5-min glucose stimulations, the colors denote different [Ca²⁺]_i waves. (C) The distributions N(p) of spatiotemporal [Ca²⁺]_i wave sizes p. The gray line indicates a power-law fit with a slope of −1.48.