Figure 5.

Experimental oscillatory stimulation: spatiotemporal organization of intercellular [Ca²⁺]_i waves in islets. (A) Typical [Ca²⁺]_i responses in four typical cells to an oscillatory stimulation with 8 mM glucose (upper panel). Oscillations are binarized and depicted for all cells within the same islet (lower panel). The gray and white areas denote glucose concentrations of 6 and 8 mM, respectively. (B) Space-time clusters of [Ca²⁺]_i activity during the second 5 min glucose stimulations, the colors denote different [Ca²⁺]_i waves. (C) The distributions N(p) of relative spatiotemporal [Ca²⁺]_i wave sizes p. The gray line indicates the power-law fit with a slope of −1.78. Note that during glucose nadirs, beta cells remain active.