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. 2017 Dec 22;8:291. doi: 10.3389/fpsyt.2017.00291

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Copyright © 2017 Guma, Devenyi, Malla, Shah, Chakravarty and Pruessner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sex differences in brief psychiatric rating scale (BPRS) negative symptom load and its interaction with amygdala surface area (SA) in males at clinical high risk (CHR). (A) Boxplot showing that males have significantly higher BPRS negative symptom load than females (p = 0.04). (B,C) Highlight areas of the amygdala SA (corresponding to the baso-lateral ventromedial nucleus in blue, and lateral nucleus in pink) associated with negative symptom severity in males at CHR. t-Statistics thresholded between 20 and 5% false discovery rate (FDR). (D) Linear regression showing negative relationship between SA and symptom severity. (E) Linear regression showing positive relationship between SA and symptom severity.