Skip to main content
. 2017 Dec 22;8:1922. doi: 10.3389/fimmu.2017.01922

Figure 6.

Figure 6

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) alters the expression profile and functionality of human dendritic cell (DC). (A–G) Gene expression analysis of nqo1 (A), akr1c1 (B), hcar2 (C), tnfa (D), il6 (E), il10 (F), and tgfb (G) in untreated and metabolite monomethyl fumarate (MMF)-treated human monocyte-derived DC (data pooled from four preparations, *p < 0.05, **p < 0.01, ***p < 0.001). (H) Proliferation rate of allogeneic T cells cultured with MMF pretreated or untreated human monocyte-derived DC as assessed by thymidine incorporation assay (data pooled from four independent experiments, **p < 0.01, ***p < 0.001 compared to ctrl, cpm = counts per minute). (I–J) Interleukin (IL)-6 (I) and tumor necrosis factor alpha (TNFα) (J) secretion by MMF pretreated or untreated human monocyte-derived DC measured in the supernatant of T cell-DC coculture assays normalized to immature DC (data pooled from three independent experiments, *p < 0.05).