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. 2017 Dec 22;10:434. doi: 10.3389/fnmol.2017.00434

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Copyright © 2017 Adotevi and Leitch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative synaptic expression of GluA1–4 in the somatosensory cortex. (A–D) Representative immunoblots showing extrasynaptic and synaptic AMPAR subunit expression; (A) GluA1, (B) GluA2, (C) GluA3 and (D) GluA4, with the loading markers PSD95 and Pan-cadherin. (E) Scatter-plot with bar graphs showing a significant decrease in AMPAR GluA1 (0.79 ± 0.07, n = 6, p < 0.05), GluA2 (0.77 ± 0.08, n = 5, p < 0.05), GluA3 (0.77 ± 0.06, n = 7, p < 0.05), GluA4 (0.66 ± 0.02, n = 5, p < 0.01) expression in stargazer (E) synaptic fractions relative to NE control littermates after normalization against Pan-cadherin. Symbols ‘^∗’ indicate p value significant digits (^∗p < 0.05, ^∗∗∗p < 0.005).