Table 1.
Summary of rat kidney tumour context, morphology, biological behaviour and immunohistochemistry findings.
| Cases | OTA Weeks | OTA Dose * µg/kg b.wt. | Age Weeks | Morphology | Dysplastic Change | Metastases | Vim | CD 10 | MMF 116 | Desmin | Others |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 UK Male | 42 | 300 (feed) | 107 | Epithelioid | No | No | + | + | − | − | |
| 2 UK Male | 42 | 300 (feed) | 105 | Epithelioid & limited spindle cell | Minimal | No | + | + | − | − | |
| 3 UK Male | 85 | 300 (feed) | 93 | Epithelioid & spindle cell/sarcomatoid | Yes | No | + | + | − | − | |
| 4 UK Male | 85 | 300 (feed) | 93 | Epithelioid & sarcomatoid | Yes, bilateral | Yes | + | − | + | − | CK7 var TTF1 − Actin − |
| 5 NTP Female | 43 | 50 by gavage | 52 | Epithelioid & sarcomatoid focally rhabdoid | No | Yes | + | − (focally weak) | variable | + areas | Actin − S100 − |
| 6 UK Male | 83 | 50 (feed) | 91 | Sarcomatoid | Yes, only contra-lateral | Yes | + | − | − | + focally | Actin + |
* Daily dose for UK cases; mean daily dose for the NTP case. Ochratoxin A (OTA); United Kingdom (UK).