Figure 3.

Subversion of autophagy during latency. (A) Herpesviruses can benefit from autophagy during latency. ➊ LMP1 encoded by EBV during latency III ➋ LMP2A during latency II, similarly to ➌ vFLIP encoded by RRV protect cell against death by stimulating autophagy (blue T bars), contributing to viral persistence and tumorigenesis. LMP1 induces autophagy either via PERK or via NF-κB. ➍ MHV68 benefits from autophagy to reactivate by limiting virus-induced inflammation (red T bar). (B) Herpesviruses can block autophagy during latency. ➎ HHV8 via vFLIP blocks autophagy to protect against oncogene-induced senescence (green T bar). ➏ The inhibition of autophagy by M11 encoded by MHV68 contributes to the maintenance of latent reservoir (orange T bar).