Figure 2.

Monkeypox virus infection can have significant impacts on multiple organ systems in the host, including the protective barriers of skin and mucosal surfaces, lymphatics, lungs, and gastrointestinal tract. Skin exfoliation can be significant, and inflammation of the airway and bronchopneumonia can lead to restricted air intake and diminished willingness and/or ability to ingest food and fluids. In rare instances, monkeypox can lead to sepsis. (Illustration: Jennifer Oosthuizen, CDC Division of Communication Services.).