Figure 4.

Central role of TAM in the immunogenic conversion of glioblastoma microenvironment upon H-1PV infection. (a) Tentative model based on existing (pre)clinical data. Interacting cells are presented with corresponding proinflammatory products (in italics if cellular source unproved). The identification of CD40⁺ myeloid cells as being denditric cells (DCs) is putative. Green and red arrows indicate activating and cytotoxic interactions, respectively. For details, see main text. T_H, helper T cell; CTL, cytotoxic T lymphocyte; GZMB, granzyme B; PERF, perforin; GBM, glioblastoma; ICD, immunogenic cell death; (b) Activated TAM (CD68, green) in CD40L-positive (red) tumor region. Scale bars: 50 μm.