Figure 3.

Graphical fit of the population pharmacokinetic (PK) model and the PK/pharmacodynamic (PD) model. (a) Plasma concentration‐time profiles of meloxicam stratified by lean body mass; circles represent observed data from Hasunuma et al.6; lines represent population predictions; colors represent CYP2C9 genotypes; gray, *1/*1; green, *1/*2; orange, *1/*3; and red, *2/*2. (b) Plasma meloxicam concentration and percent serum thromboxane B₂ (TXB₂) generation relative to basal value‐time profiles; left upper panel, plasma concentration profile after administration of 15 mg of meloxicam; right upper panel, profiles for percent serum TXB₂ generation relative to the basal value; left and right lower panel, PK and PD residuals plots. Plasma meloxicam concentration plots represent data from Bae et al.,14 and plots of percent serum TXB₂ generation were calculated as the difference between 100% and the scanned percent inhibition of TXB₂ generation. Circles represent observed average data. Lines represent predictions. Colors represent CYP2C9 genotypes; green, *1/*1; and orange, *1/*13. Error bars represent SDs. The SDs at 1–8 hours after administration were not digitized because the error bars were not recognized for all groups.