Figure 2.

The effects of IMA treatment on tumor nanoparticle delivery. (A) In vivo fluorescence imaging of A549 xenograft-bearing mice (the upper row) treated with IMA or water as a control, ex vivo fluorescence imaging of their corresponding tumor xenografts (the lower row), and (B) the relative signal intensity of tumor tissue 24 h post the injection of DiR-labeled nanoparticles or micelles. ^*p < 0.05, compared with Control+NP group. ^**p < 0.01 compared with IMA+Micelles group. (C) In vivo distribution of micelles and nanoparticles in tumor slices from A549 tumor xenograft-bearing mouse models treated with IMA or water at 24 h after i.v. injection of a mixture of DiD-labeled nanoparticles and coumarin-6-labeled micelles. The oral dose of IMA was 50 mg/kg/d for 3 weeks. The dose of both coumarin-6 and DiD was 0.05 mg/kg. The bar indicated 100 μm. Reprinted from reference with permission by copyright holder, Zhiqing Pang.