TABLE 1.

Summary of the clinical isolates and mutants and status of the genes associated with fosfomycin resistance

Strain	Fosfomycin MIC (μg/ml)	ST	murA	ptsI	cyaA	glpT	uhpA	uhpC	uhpT	Growth without glucose-6-phosphate	Mutation frequency
S59	16	131								+	∼10−10
S60	64		Intact	Intact	Intact	Intact	Absent	Absent	Absent	−
S61	2	405								+	∼10−8
S62	512		Intact	Intact	Intact	Intact	Absent	Absent	Absent	−
S65	256	131								+	∼10−7
S66	>1,024		Intact	Intact	Intact	Intact	Truncated	Intact	Intact	−
S67	2	4981								+	∼10−11
S68	64		Intact	Intact	Intact	Intact	Absent	Absent	Absent	−
S69	8	624								+	∼10−11
S70	64		Intact	Intact	Intact	Intact	Absent	Absent	Absent	−