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. 2017 Dec 22;8:714. doi: 10.3389/fneur.2017.00714

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Copyright © 2017 Wu, Liao, Zhan, Cheng, Shen, Huang, Zhou, Wang, Qiu, Xing, Liao, Tang and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tract-based spatial statistics analysis of the FA in spinocerebellar ataxia type 3 (SCA3) patients compared with healthy controls. SCA3 group showed decreased FA value of the mean white matter (WM) skeleton in the whole brain (A,B) (green represents mean FA skeleton, red–yellow represents to set the display range to 0.95:1, p < 0.05, corrected). A negative correlation was found between the total FA value of the mean WM skeleton and the total International Cooperative Ataxia Rating Scale (ICARS) scores (C) and its subscale of kinetic function (D) in SCA3 patients.