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. 2017 Dec 22;9:416. doi: 10.3389/fnagi.2017.00416

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Copyright © 2017 Ferguson, Mouzon, Lynch, Lungmus, Morin, Crynen, Carper, Bieler, Mufson, Stewart, Mullan and Crawford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of repetitive mild traumatic brain injury (r-mTBI) on rotarod performance in (A) young and (B) aged hTau mice. Values were recorded with a total of 4 trials within a week after the last injury/anesthesia with three 5 min accelerating trials. Results are the mean ± SEM of the time animals remained on the rotarod before falling and normalized to baseline. There was no impairment with multiply injured animals in young male and female between days 1 and 7 of testing after last mTBI or anesthesia (p > 0.05). In the aged cohort, Female TBI mice performed worse than their sham counterparts (p < 0.001) and worse than the male r-mTBI group (p < 0.001) on all days of Rotarod testing. ^*p < 0.05.