HPgV and HCV genome organization and phylogenetic relationships. (a, b) Whilst HPgV (a) is within the genus Pegivirus and HCV (b) is within the genus Hepacivirus of the family Flaviviridae, both viruses share many features, including a ssRNA positive-sense genome with 59 and 39 NTRs. Both viruses are capable of causing persistent human infection. (c, d) HPgV and HCV phylogenetic trees (unweighted pair group method with arithmetic mean) (c) were reconstructed in mega6 using alignments of isolates with GenBank numbers shown in (d). The original tree without bootstrapping is shown. gt, Genotype.