Table 4.
Factors associated with rifampin plasma concentrations below target maximum concentration
| Characteristic | Cmax ≥ 8 μg/mL (N = 39) | Cmax < 8 μg/mL (N = 61) | P-value |
|---|---|---|---|
| Median (IQR) age (years) | 6.9 (2.4 – 8.9) | 4.6 (2.0 – 7.0) | 0.264 |
| Median (IQR) body weight (Kg) | 16.3 (8.8 – 21.0) | 13.0 (8.5 – 17.4) | 0.101 |
| Median (IQR) height (Cm) | 106.0 (84.0 – 123.0) | 94.0 (82.0 – 111.0) | 0.070 |
| Nutritional status | |||
| Median (IQR) weight-for-age Z score* | −2.3 (−3.7 – −1.0) | −2.8 (−4.0 – −1.6) | 0.280 |
| Median (IQR) height-for-age Z score | −1.6 (−2.8 – −0.5) | −2.6 (−3.4 – −1.7) | 0.004 |
| Median (IQR) BMI-for-age Z score | −1.6 (−2.8 – −0.5) | −2.6 (−3.4 – −1.7) | 0.538 |
| Median (IQR) mid-arm circumference | 13.8 (12.9 – 16.5) | 13.3 (11.2 – 15.0) | 0.369 |
| Median (IQR) drug dose (mg/kg) | 17.6 (15.8 – 19.0) | 15.5 (14.1 – 18.8) | 0.043 |
| Age (years) n (%) | 0.808 | ||
| < 2 | 8 (34.8%) | 15 (65.2%) | |
| ≥ 2 | 31 (40.3%) | 46 (59.7%) | |
| Age (years) n (%) | 0.224 | ||
| < 5 | 16 (32.7%) | 33 (67.3%) | |
| ≥ 5 | 23 ((45.1%) | 28 (54.9%) | |
| Sex | 0.305 | ||
| Female | 19 (45.2%) | 23 (54.8%) | |
| Male | 20 (34.5%) | 38 (65.5%) | |
| HIV positive | 0.100 | ||
| No | 24 (48.0%) | 26 (52.0%) | |
| Yes | 15 (30.0%) | 35 (70.0%) | |