Table.
Histotype | CD8+ TILs | N | Person-Years | % events | HR (95% CI) | P value trend | P value 3 d.f. |
---|---|---|---|---|---|---|---|
High-grade serous | Negative | 546 | 1,709.75 | 76.2% | ref | 4.2 × 10−16 | 7.2 × 10−15 |
Low | 546 | 1,908.39 | 72.3% | 0.86 (0.75–0.99) | |||
Moderate | 1,394 | 5,264.82 | 69.0% | 0.77 (0.69–0.87) | |||
High | 710 | 3,110.87 | 56.5% | 0.57 (0.49–0.65) | |||
| |||||||
Endometrioid | Negative | 206 | 1,118.53 | 33.5% | ref | 0.0084 | 0.006 |
Low | 130 | 675.44 | 34.6% | 0.80 (0.54–1.18) | |||
Moderate | 283 | 1,844.53 | 18.0% | 0.50 (0.34–0.74) | |||
High | 110 | 657.59 | 22.7% | 0.76 (0.47–1.23) | |||
| |||||||
Clear cell | Negative | 309 | 1,640.28 | 41.1% | ref | 0.50 | 0.52 |
Low | 141 | 658.25 | 45.4% | 1.16 (0.84–1.60) | |||
Moderate | 118 | 618.79 | 41.5% | 0.88 (0.62–1.24) | |||
High | 80 | 412.44 | 40.0% | 0.92 (0.61–1.39) | |||
| |||||||
Mucinous | Negative | 168 | 750.75 | 44.0% | ref | 0.037 | 0.16 |
Low | 77 | 375.26 | 31.2% | 0.91 (0.55–1.51) | |||
Moderate | 85 | 470.62 | 27.1% | 0.56 (0.34–0.93) | |||
High | 13 | 72.35 | 23.1% | 0.79 (0.23–2.68) | |||
| |||||||
Low-grade serous | Negative | 43 | 198.06 | 48.8% | ref | 0.91 | 0.996 |
Low | 44 | 184.89 | 65.9% | 0.94 (0.50–1.74) | |||
Moderate | 63 | 272.13 | 47.6% | 0.98 (0.52–1.83) | |||
High | 12 | 49.53 | 41.7% | 0.92 (0.33–2.59) |
Adjusted for study, age (continuous), and stage (I/II, III/IV, unknown); levels based on counts of TIL per high-powered field: negative, none; low, 1–2; moderate, 3–19; high, 20+; HR, hazard ratio; CI, confidence interval; P value trend, from a one degree-of-freedom trend test; P value 3 d.f., from an unordered three degree-of-freedom test.