Table.

Multivariate-adjusted association of CD8⁺ tumor-infiltrating lymphocytes (TIL) and overall survival among cases with the five most common invasive epithelial ovarian cancer histotype (N=5,078)

Histotype	CD8+ TILs	N	Person-Years	% events	HR (95% CI)	P value trend	P value 3 d.f.
High-grade serous	Negative	546	1,709.75	76.2%	ref	4.2 × 10−16	7.2 × 10−15
	Low	546	1,908.39	72.3%	0.86 (0.75–0.99)
	Moderate	1,394	5,264.82	69.0%	0.77 (0.69–0.87)
	High	710	3,110.87	56.5%	0.57 (0.49–0.65)
Endometrioid	Negative	206	1,118.53	33.5%	ref	0.0084	0.006
	Low	130	675.44	34.6%	0.80 (0.54–1.18)
	Moderate	283	1,844.53	18.0%	0.50 (0.34–0.74)
	High	110	657.59	22.7%	0.76 (0.47–1.23)
Clear cell	Negative	309	1,640.28	41.1%	ref	0.50	0.52
	Low	141	658.25	45.4%	1.16 (0.84–1.60)
	Moderate	118	618.79	41.5%	0.88 (0.62–1.24)
	High	80	412.44	40.0%	0.92 (0.61–1.39)
Mucinous	Negative	168	750.75	44.0%	ref	0.037	0.16
	Low	77	375.26	31.2%	0.91 (0.55–1.51)
	Moderate	85	470.62	27.1%	0.56 (0.34–0.93)
	High	13	72.35	23.1%	0.79 (0.23–2.68)
Low-grade serous	Negative	43	198.06	48.8%	ref	0.91	0.996
	Low	44	184.89	65.9%	0.94 (0.50–1.74)
	Moderate	63	272.13	47.6%	0.98 (0.52–1.83)
	High	12	49.53	41.7%	0.92 (0.33–2.59)

Adjusted for study, age (continuous), and stage (I/II, III/IV, unknown); levels based on counts of TIL per high-powered field: negative, none; low, 1–2; moderate, 3–19; high, 20+; HR, hazard ratio; CI, confidence interval; P value trend, from a one degree-of-freedom trend test; P value 3 d.f., from an unordered three degree-of-freedom test.