Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) The reaction catalyzed by wild-type IDH is the decarboxylation of isocitrate to α-ketoglutarate. (B) The reaction catalyzed by mutant IDH1 and IDH2 is the reduction of α-ketoglutarate to D-2-hydroxyglutarate. (C) Structures of AG-120 (ivosidenib) and AG-221 (enasidenib), which inhibit mutant IDH1 and IDH2 respectively.
