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Evolutionary trees based on trypanosomatid housekeeping genes APRT(adenine phosphoribosyl transferase), GSH1 (γ-glutamylcysteine synthetase), and PTR1 (pteridine reductase 1). The scale corresponds to the degree of evolutionary divergence among these organisms. Lineages lacking RNAi genes are colored red, while RNAi-proficient lineages are colored blue
