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. 2017 Jul 19;125(7):077013. doi: 10.1289/EHP793

Table 2.

Incident AMD and ever use of specific pesticides in pesticide applicators and their spouses, AHS 1993-2007.

  Case Control ORa 95% CI
n % n %
Insecticides (any) 126 78 28558 73 1.6 1.1 2.5
 Organochlorines (any) 98 62 14870 38 2.7 1.8 4.0
  Aldrin 37 26 5433 15 1.5 0.95 2.3
  Chlordane 61 42 7696 21 2.4 1.7 3.6
  DDT 70 47 7728 21 2.1 1.4 3.1
  Dieldrin 21 15 1960 5 1.9 1.1 3.2
  Heptachlor 36 26 4490 12 1.9 1.2 3.0
  Lindane 32 22 5148 14 1.9 1.2 3.0
  Toxaphene 27 19 3957 11 1.5 0.9 2.3
 Organophosphates (any) 117 73 25157 64 2.0 1.3 3.0
  Chlorpyrifos 45 29 10522 27 1.3 0.9 1.9
  Coumaphos 10 7 2302 6 1.1 0.6 2.2
  Diazinon 58 40 9404 26 2.0 1.4 2.9
  Dichlorvos 18 12 3121 9 1.8 1.1 3.0
  Fonofos 20 14 5463 15 1.0 0.6 1.7
  Malathion 103 68 19889 53 2.2 1.5 3.3
  Parathion 28 20 3877 11 1.9 1.2 3.0
  Phorate 42 30 8070 22 1.7 1.1 2.6
  Terbufos 35 24 9210 25 1.1 0.7 1.7
 Other insecticides              
  Aldicarb 5 4 2511 7 0.5 0.2 1.3
  Carbaryl 91 61 18890 51 1.4 0.99 2.0
  Carbofuran 31 21 7231 20 1.1 0.7 1.7
  Permethrin (crops) 16 11 3197 9 1.8 1.03 3.0
  Permethrin (animals) 11 8 3541 10 1.3 0.7 2.4
Herbicides (any) 119 74 28973 74 1.2 0.8 1.9
 Phenoxyacetate (any) 101 64 21222 55 1.9 1.2 2.8
  2,4,5-T 46 32 5841 16 2.0 1.3 3.0
  2,4,5-TP 18 13 2390 7 1.7 1.03 2.9
  2,4-D 98 62 20689 54 1.8 1.2 2.7
 Triazine (any) 79 50 19414 50 1.2 0.7 1.8
  Atrazine 74 47 17889 47 1.2 0.8 1.8
  Cyanazine 41 28 10175 28 1.3 0.9 2.0
  Metribuzin 40 28 10756 30 1.2 0.8 1.9
 Other herbicides              
  Alachlor 59 39 13154 36 1.4 0.9 2.1
  Butylate 30 21 7886 22 1.2 0.7 1.8
  Chlorimuron ethyl 28 20 7887 22 1.2 0.7 1.9
  Dicamba 44 30 12012 33 1.1 0.7 1.7
  EPTC 17 12 4618 13 1.2 0.7 2.0
  Glyphosate 103 64 23493 61 1.4 0.99 2.0
  Imazethapyr 32 23 9503 26 1.1 0.7 1.8
  Metolachlor 41 28 10728 29 1.2 0.8 1.8
  Paraquat 30 20 5542 15 1.5 0.9 2.3
  Pendimethalin 31 22 9912 27 0.9 0.6 1.4
  Petroleum oil 39 27 11165 31 0.9 0.6 1.4
  Trifluralin 51 36 12775 35 1.2 0.8 1.9
Fungicides (any) 51 32 9337 24 1.5 1.04 2.1
  Benomyl 18 12 2548 7 1.7 0.99 2.8
  Captan 20 14 3009 8 2.0 1.2 3.3
  Chlorothalonil 11 7 1965 5 1.2 0.7 2.3
  Maneb 13 9 2627 7 1.1 0.6 2.0
  Metalaxyl 24 17 5459 15 1.1 0.7 1.8
Fumigants (any) 28 18 6032 16 1.0 0.6 1.5
  Carbon tetrachloride 11 8 1542 4 1.4 0.7 2.6
  Ethylene dibromide 10 7 884 2 2.8 1.5 5.6
  Methyl bromide 17 11 4106 11 0.8 0.5 1.4

Note: AHS, Agricultrual Health Study; AMD, age-related macular degeneration; BMI, body mass index; CI, confidence interval; DDT, dichlorodiphenyltrichloroethane; EPTC, S-ethyl dipropylthiocarbamate; OR, odds ratio. 2,4-D, 2,4-dichlorophenoxyacetic acid; 2,4,5-T, 2,4,5-trichlorophenoxyacetic acid; 2,4,5,-TP, 2-propionic acid (fenoprop).

a

Adjusted for age, gender, and smoking.