Table 1.
Baseline characteristics of patients with and without exacerbation
| Characteristics | Patients with an exacerbation (n=45) | Patients without an exacerbation (n=76) | P-value |
|---|---|---|---|
| Age, years | 70.5±7.1 | 71.9±7.9 | 0.33 |
| Male | 44 (97.8) | 74 (97.4) | 0.89 |
| BMI, kg/m2 | 23.6±3.5 | 22.6±3.0 | 0.13 |
| Smoking status | |||
| Former smoker | 31 (72.1) | 55 (73.3) | 0.88 |
| Current smoker | 12 (27.9) | 20 (26.7) | |
| Pack-years | 51.4±30.3 | 45.9±22.2 | 0.25 |
| History of exacerbation in the past year | |||
| Exacerbations (yes, %) | 26 (57.8) | 22 (28.9) | <0.01 |
| Frequency of exacerbation (no/year) | 1.9±3.2 | 0.5±1.3 | <0.01 |
| Lung function | |||
| FEV1, L | 1.5±0.5 | 1.7±0.5 | 0.06 |
| FEV1, % | 60.6±18.1 | 68.3±19.3 | 0.03 |
| FVC, L | 3.5±0.8 | 3.5±0.8 | 0.64 |
| FVC, % | 94.8±20.8 | 95.2±18.2 | 0.90 |
| FEV1/FVC | 43.0±11.2 | 48.7±10.3 | <0.01 |
| GOLD grade | |||
| 1 (FEV1>80% predicted) | 4 (8.9) | 19 (25.0) | 0.03 |
| 2 (FEV1 50%–79% predicted) | 28 (62.2) | 43 (56.6) | |
| 3 (FEV1 30%–49% predicted) | 10 (22.2) | 14 (18.4) | |
| 4 (FEV1 <30% predicted) | 3 (6.7) | 0 (0) | |
| SGRQ score | 40.3±19.5 | 34.7±17.7 | 0.11 |
| mMRC grade | 1.4±0.8 | 1.4±0.9 | 0.81 |
| 6MWD, m | 443.0±109.7 | 424.5±124.3 | 0.43 |
| CAT score | 19.5±8.4 | 16.2±7.3 | 0.02 |
| CCQ score | 2.1±1.0 | 1.9±0.9 | 0.28 |
Note: Data are presented as number (%) or mean ± standard deviation.
Abbreviations: BMI, body mass index; CAT, COPD Assessment Test; CCQ, Clinical COPD Questionnaire; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; GOLD, Global Initiative for Chronic Obstructive Lung Disease; mMRC, modified Medical Research Council; 6MWD, 6-minute walk distance; SGRQ, St George’s Respiratory Questionnaire.