Table 1.
Subject characteristics at rest for 93 COPD patients with and without pulmonary hypertension
| Characteristics | mPAP <25 mmHg (n=71) | mPAP ≥25 mmHg (n=22) | P-value |
|---|---|---|---|
| Gender, female % | 49 | 59 | 0.43 |
| Age, yearsa | 64 (6) | 61 (8) | 0.19 |
| Height, cma | 169 (9) | 169 (11) | 0.65 |
| Weight, kg | 71 (17) | 70 (20) | 0.93 |
| BMI, kg/m2 | 25 (4) | 25 (6) | 0.91 |
| mPAP, mmHg | 18.0 (3.5) | 28.7 (4.6) | <0.001 |
| PCWP, mmHg | 8.4 (3.8) | 11.0 (3.0) | 0.004 |
| PVR, WU | 2.0 (0.9) | 3.4 (1.5) | <0.001 |
| TPG, mmHga | 9.6 (3.5) | 17.7 (6.4) | <0.001 |
| CO, L/min | 5.1 (0.9) | 5.5 (1.2) | 0.11 |
| CI, L/min/m2a | 2.8 (0.4) | 3.1 (0.5) | 0.06 |
| Systemic SBP, mmHg | 141 (23) | 139 (19) | 0.71 |
| Systemic DBP, mmHg | 69 (11) | 66 (10) | 0.25 |
| Systemic MAP, mmHg | 95 (14) | 93 (10) | 0.47 |
| Heart rate, beats/min | 89 (17) | 96 (18) | 0.08 |
| FEV1 %pred | 47 (16) | 29 (9) | <0.001 |
| FVC %pred | 77 (20) | 59 (16) | <0.001 |
| FEV1/FVC% | 50 (10) | 41 (11) | 0.001 |
| TLC %pred | 123 (20) | 136 (26) | 0.05 |
| RV %preda | 193 (59) | 253 (57) | <0.001 |
| RV/TLC %a | 58 (11) | 69 (9) | <0.001 |
| DLCO %pred | 57 (19) | 30 (14) | <0.001 |
| MVV, L/mina | 55 (25) | 34 (12) | <0.001 |
| PaO2, mmHg | 74 (9) | 61 (11) | <0.001 |
| PaCO2, mmHg | 40 (5) | 44 (5) | 0.005 |
| SaO2, %a | 96 (2) | 92 (5) | 0.001 |
Notes: Values are presented as mean (SD) or %.
Nonparametric test. For TLC and RV, n=90. For DLCO, n=83. P-values are shown in bold for significant differences.
Abbreviations: BMI, body mass index; CI, cardiac index; CO, cardiac output; COPD, chronic obstructive pulmonary disease; DBP, diastolic blood pressure; DLCO, diffusion capacity of the lung for carbon monoxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; MAP, mean arterial pressure; mPAP, mean pulmonary artery pressure; MVV, maximum voluntary ventilation; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; PCWP, pulmonary capillary wedge pressure; PVR, pulmonary vascular resistance; RV, residual volume; SaO2, oxygen saturation; SBP, systolic blood pressure; SD, standard deviation; TLC, total lung capacity; TPG, transpulmonary pressure gradient.