Table 4.

Association between inflammation, pain and cold pressor test responses before and after multivariable adjustment.

	N	Univariablea		Multivariableb
		Rho	P	R2	F	P
Dependent variable: ∆ HR CPT
TNF-α	60	0.254	0.050	0.175	4.715	0.034⁎
Ln (TNF-α + 1)				0.199	6.392	0.015⁎
IL-10	60	0.299	0.020	0.196	6.192	0.016⁎
Ln (IL-10 + 1)				0.199	6.425	0.014⁎
DAS28-CRPc	28	− 0.308	0.111	0.399	0.901	0.354
Dependent variable: ∆ Mean BP CPT
TNF-α	60	0.232	0.074	0.094	0.724	0.399
Ln (TNF-α + 1)				0.118	2.160	0.148
IL-10	60	− 0.179	0.171	0.143	3.783	0.057
Ln (IL-10 + 1)				0.119	2.223	0.142
Dependent variable: ∆ Systolic BP CPT
IL-10	60	0.112	0.395	0.133	3.396	0.071
Ln (IL-10 + 1)				0.089	0.701	0.406
Dependent variable: ∆ Diastolic BP CPT
TNF-α	60	0.245	0.059	0.077	1.664	0.203
Ln (TNF-α + 1)				0.105	3.339	0.073
IL-10	60	0.212	0.103	0.109	3.536	0.066
Ln (IL-10 + 1)				0.101	3.086	0.085

^aSpearman's rank.

^bAfter adjustment for age, sex, BMI, presence of hypertension, RA diagnosis and haemoglobin concentration.

^cAfter adjustment for age, sex, BMI, presence of hypertension, haemoglobin concentration and RA duration.

^⁎p < 0.05.