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. Author manuscript; available in PMC: 2018 Dec 21.
Published in final edited form as: Mol Cell. 2017 Dec 21;68(6):1067–1082.e12. doi: 10.1016/j.molcel.2017.11.026

Figure 4. AP-1 TFs bind inducibly to LRG enhancers.

Figure 4

a) Representative genome browser tracks of the enhancers downstream from the Vegfa gene showing binding of AP-1 TFs expressed in quiescent MEFs (Jund, Fosl2) as well as the inducible AP-1 TF Fos. Shaded boxes indicate LRG enhancers. Scale bars indicate normalized read densities for each ChIP-seq (0 and 90m are displayed on the same scale for each track). b) Percentages of LRG and cell identity enhancers, as well as the TSSs of LRGs, that are bound by AP-1 TFs in quiescent and stimulated MEFs. c–d) Fixed line plots (c) and aggregate plots (d) of enhancer associated histone modifications at LRG and cell identity enhancers before and after stimulation.