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. Author manuscript; available in PMC: 2018 Oct 22.
Published in final edited form as: Ann Neurol. 2017 Oct 22;82(4):602–614. doi: 10.1002/ana.25049

FIGURE 1.

FIGURE 1

Highly optimized three-dimensional modeling of dendritic spines in controls, CAD, and AD cases. (A, C, E) Representative brightfield images of Golgi-impregnated dendrites. Scale bars represent 5 μm. (B, D, F) Three-dimensional digital reconstructions of the same dendrites generated in Neurolucida360. (G) (Left to Right) Representative zoomed-in brightfield image of a single Golgi-impregnated spine in the XY plane. Three-dimensional digital reconstruction of the spine in the XY plane with a grey line representing the head diameter measurement. Clockwise rotation in XYZ dimensions with a grey line representing the spine extent measurement. Further rotation in XYZ with grey lines representing spine head diameter and extent.