Linear regression analysis of spine density and AD pathology. (A) Spine density does not correlate with neuritic plaque score. (B) Spine density does not correlate with diffuse plaque score. (C) There is negative correlation of spine density with NFT score (F1,39=6.495, R2=0.1428, P=0.0149). (D) There is negative correlation of spine density with Braak staging (F1,37=11.63, R2=0.2392, P=0.0016). (E) Spine density does not correlate with Braak staging among AD cases. Dashed lines represent 95% confidence intervals. NFT, neurofibrillary tangle.