TABLE 2.
Pathology data on postmortem human brain tissue samples.
| Cases | Frontal NP | Frontal DP | Frontal NFT | Braak Stage | CERAD Score | ABC Score |
|---|---|---|---|---|---|---|
| Control (N =12) | ||||||
| 1 | none | frequent | none | 0 | B | Low |
| 2 | none | none | none | I | 0 | None |
| 3 | none | none | none | II | 0 | None |
| 4 | sparse | frequent | none | III | A | Low |
| 5 | none | none | none | I | 0 | None |
| 6 | none | sparse | none | II | 0 | Low |
| 7 | none | none | none | I | 0 | None |
| 8 | none | moderate | none | II | 0 | Low |
| 9 | none | none | none | II | 0 | None |
| 10 | none | none | sparse | III | 0 | None |
| 11 | none | sparse | none | II | 0 | None |
| 12 | none | moderate | none | I | 0 | None |
| CAD (N = 8) | ||||||
| 1 | frequent | moderate | none | IV | C | Intermediate |
| 2 | sparse | moderate | none | II | B | Low |
| 3 | frequent | frequent | sparse | II | C | Low |
| 4 | frequent | frequent | none | III | C | Intermediate |
| 5 | frequent | frequent | none | IV | C | Intermediate |
| 6 | frequent | frequent | sparse | IV | C | Intermediate |
| 7 | moderate | none | sparse | I | B | Intermediate |
| 8 | frequent | frequent | sparse | III | C | Intermediate |
| AD (N = 21) | ||||||
| 1 | frequent | frequent | sparse | IV | C | Intermediate |
| 2 | frequent | frequent | none | III | C | Intermediate |
| 3 | frequent | frequent | none | III | C | Intermediate |
| 4 | frequent | moderate | none | II | C | Low |
| 5 | moderate | frequent | sparse | IV | C | Intermediate |
| 6 | frequent | frequent | frequent | VI | C | Intermediate |
| 7 | frequent | frequent | sparse | I | C | Low |
| 8 | frequent | moderate | sparse | IV | C | Intermediate |
| 9 | frequent | moderate | sparse | IV | C | Intermediate |
| 10 | frequent | frequent | sparse | IV | C | Intermediate |
| 11 | sparse | frequent | sparse | IV | C | Intermediate |
| 12 | frequent | sparse | frequent | V | C | High |
| 13 | frequent | none | frequent | V–VI | C | High |
| 14 | frequent | frequent | moderate | VI | C | High |
| 15 | frequent | moderate | frequent | VI | C | High |
| 16 | frequent | frequent | frequent | VI | C | High |
| 17 | frequent | frequent | frequent | VI | C | High |
| 18 | frequent | frequent | moderate | VI | C | High |
| 19 | frequent | frequent | frequent | VI | C | High |
| 20 | frequent | moderate | moderate | VI | C | High |
| 21 | frequent | none | frequent | VI | C | High |
Twelve cognitively normal, age-equivalent, pathology-free controls were compared to 8 cognitively normal controls with Alzheimer’s disease (AD) pathology (CAD) and 21 sporadic AD cases. NP, neuritic Aβ plaque; DP, diffuse Aβ plaque; CERAD, Consortium to Establish a Registry for Alzheimer’s disease; ABC, Amyloid Braak CERAD score.