Table 2. Independent effects of markers of environmetal enteric dysfunction on seroconversion post dose 2 among rotavirus vaccinated infants aged 6–11 weeks.
| Biomarkers | Crude RR (95%CI) | P-value | Adjusted RR (95%CI) 1 | Adjusted P-value |
|---|---|---|---|---|
| Zonulin | ||||
| Titre transformed to log base 2 | 1.26 (1.14, 1.40) | <0.0001 | 1.24 (1.12, 1.37) | <0.0001 |
| Soluble CD14 | ||||
| Titre transformed to log base 2 | 0.91 (0.71, 1.16) | 0.438 | 0.91 (0.73, 1.13) | 0.380 |
| EndoCaB | ||||
| Titre transformed to log base 2 | 0.92 (0.79, 1.08) | 0.307 | 0.98 (0.85, 1.14) | 0.807 |
| IFABP | ||||
| Titre transformed to log base 2 | 1.11 (1.06, 1.17) | <0.0001 | 1.07 (1.02, 1.13) | 0.006 |
1 Estimates were adjusted for biomarkers (transformed on log base 2); and Age of child at vaccination (binary); Breast-milk anti-rotavirus IgA (transformed on log base 2); Seropositivity at baseline (IgA > = 1:40) (binary); Infant serum anti-rotavirus IgG (transformed on log base 2)