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. 2017 Dec 27;12(12):e0190275. doi: 10.1371/journal.pone.0190275

Fig 2. Reversible dual G9a/DNMT inhibitor activity increases reprogramming efficiency.

Fig 2

(A) Schematic representation of the reprogramming process. (B) Quantification of AP+ colonies at day 30 of cell reprogramming in cells treated with CM272 at the indicated times related to doxycycline induction. Mock indicates no CM272 treatment. Error bars denote SD of three independent experiments. (C, D and E) Quantification of AP+ colonies at day 30 of cell reprogramming in cells treated with BIX-01294 or CM272 at the indicated doses (C), in primary cells treated with CM272 (D), and in BJ cells infected with the indicated mixtures of TFs (E). Fold increase over mock is indicated. Mock indicates no CM272 treatment. Circles ADSCs; Squares fibroblasts; Triangles PH1-fibroblasts. Kruskal-Wallis with Dunn’s test as a post-hoc was used. * p<0.05, ** p<0.01, *** p<0.001, ns: not significative.