Table 2.

Residues Contributing Most to the Mutual Information between the Ligand Binding Pocket and the Intracellular Region of the MOR^a

TRV-130-bound MOR		morphine-bound MOR
residue/ligand	contribution	residue/ligand	contribution
TRV-130	0.56	D1643.49	0.75
Y1062.42	0.44	F1082.44	0.65
W133(EC1)	0.42	Y1062.42	0.56
Y1493.34	0.4	I1072.43	0.55
Y3267.43	0.37	F343(H8)	0.54
F343(H8)	0.36	N1884.46	0.54
F347(H8)	0.35	F135(EC1)	0.53
R1653.50	0.35	R2776.32	0.52
W2936.48	0.34	F1563.41	0.50
W3187.35	0.34	W133(EC1)	0.50
Y911.55	0.34	N861.50	0.49
Y3367.53	0.33	I1443.29	0.48
F178(IC2)	0.33	Y961.60	0.48
E2295.35	0.33	N1092.45	0.48
F135(EC1)	0.33	C1403.25	0.47
D1643.49	0.32	N3327.49	0.46
I1443.29	0.31	P134(EC1)	0.46
T1603.45	0.29	morphine	0.45
Y2525.58	0.29	Y2996.54	0.45
		W2936.48	0.45
		Y3267.43	0.45
		Y3367.53	0.44

^aResidues completely exposed to the lipid bilayer are not included in the table. Common residues in the two systems are highlighted in bold.