Table 2.
Single marker analysis. Allele association results
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| Advanced AMD | Exudative AMD | Athrophic AMD | Mixed AMD | ||||||||
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| Gene | SNP | MAF | Alleles | OR (95% CI) |
P value (Perm. P value)* |
OR (95% CI) |
P value (Perm. P value)* |
OR (95% CI) |
P value (Perm. P value)* |
OR (95% CI) |
P value (Perm. P value)* |
| ABCA4 | rs3112831 | 0,37 | A/G | 1.47 (1.84–1.15) | 0.0015 (0.0369) | 1.01 (1.31–0.79) | 0.027 (0.6537) | 1.84 (2.88–1.19) | 0.006 (0.2428) | 1.58 (2.36–1.06) | 0.0252 (0.8171) |
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| CFH | rs800292 | 0,154 | C/T | 1.68 (2.29–1.24) | 0.0009 (0.0374) | 1.73 (2.47–1.21) | 0.0022 (0.0991) | 1.01 (1.68–0.6) | 0,9758 | 2.83 (5.41–1.47) | 0.0012 (0.0350) |
| CFH | rs3766404 | 0,133 | T/C | 2.21 (3.08–1.58) | 2.17×10−06 (0.0001) | 2.12 (3.1–1.45) | 8.87×10−05 (0.0043) | 2.62 (5.35–1.28) | 0.003 (0.2518) | 2.23 (4.1–1.21) | 0.0084 (0.2695) |
| CFH | rs1329421 | 0,44 | T/A | 2.04 (2.57–1.62) | 8.12×10−10 (< 0.0001) | 1.87 (2.42–1.45) | 1.27×10−06 (< 0.0001) | 2.19 (3.3–1.46) | 0.0001 (0.0076) | 2.54 (3.71–1.74) | 8.15×10−07 (0.0002) |
| CFH | rs1831282 | 0,47 | T/G | 2 (2.52–1.6) | 1.86×10−09 (< 0.0001) | 1.84 (2.37–1.43) | 2.23×10−06 (< 0.0001) | 2.06 (3.1–1.37) | 0.0004 (0.0249) | 2.58 (3.77–1.76) | 6.79×10−07 (0.0002) |
| CFH | rs12144939 | 0,183 | G/T | 2.35 (3.15–1.75) | 6.23×10−09 (< 0.0001) | 2.33 (3.26–1.66) | 5.52×10−7 (< 0.0001) | 2.89 (5.41–1.54) | 0.0006 (0.0323) | 2.07 (3.45–1.24) | 0.0044 (0.1890) |
| CFH | rs2284664 | 0,13 | G/A | 1.71 (2.33–1.21) | 0.002 (0.0395) | 1.83 (2.69–1.24) | 0.002 (0.0905) | 1.03 (1.77–0.6) | 0,9126 | 2.31 (4.45–1.2) | 0.0102 (0.2988) |
| CFH | rs1329428 | 0,31 | G/A | 2.49 (3.19–1.95) | 2.13×10−13 (< 0.0001) | 2.65 (3.52–1.99) | 9.91×10−12 (< 0.0001) | 1.96 (3.08–1.25) | 0.003 (0.1356) | 2.54 (3.94–1.64) | 2.11×10−05 (0.0020) |
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| FGF2 | rs6820411 | 0,122 | A/C | 1.96 (2.83–1.36) | 0.0002 (0.0043) | 1.76 (2.63–1.17) | 0.0057 (0.092) | 2.63 (4.58–1.51) | 0.0004 (0.0144) | 2.13 (3.64–1.24) | 0.0052 (0.0977) |
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| LOC387715 | rs10490924 | 0,324 | T/G | 3.94 (5.14–3.02) | 1.75×10−25 (< 0.0001) | 4.20 (5.61–3.15) | 7.46×10−24 (< 0.0001) | 3.56 (5.49–2.31) | 9.12×10−09 (< 0.0001) | 3.48 (5.19–2.33) | 1.07×10−09 (< 0.0001) |
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| CGREF1 | rs2384571 | 0,453 | C/G | 1.2 (1.51–0.97) | 0,0983 | 1.84 (2.8–1.2) | 0.0045 (0.0484) | ||||
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| APOE | rs7259004 | 0,102 | C/G | 1.08 (1.56–0.75) | 0,6905 | 2.22 (3.68–1.34) | 0.0015 (0.0199) | ||||
OR= Odds ratios
Perm. P value= P value from 10.000 permutations
*
Significant P values (<0.05) are shown in bold