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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Am J Addict. 2017 Aug 31;26(7):751–759. doi: 10.1111/ajad.12607

Figure 3.

Figure 3

Habenula/striatum resting state functional connectivity (Hb/Str RSFC) in opioid users and psychiatric patient controls. A) RSFC between the right and the left habenula (RHb, LHb) and the whole striatum (composed of caudate, putamen and globus pallidus). B) RSFC between the right and the left habenula and each sub-region of the striatum. No op: patients with no opioid use, Op: patients with opioid use. * p<0.05. C) Right habenula/left caudate connectivity and alpha 5 nicotinic acetylcholine receptor subunit genetic variant rs16969968 genotype. The low risk GG genotype shows increased connectivity in opioid-dependent patients compared to those carrying an A-allele and non-opioid users with GG genotype. No opi: patients with no opioid use, opi, patients with opioid use. * p<0.05 (LSD).