Fig. 2.

Routine for detection of inner boundary of ellipsoid zone (EZ) location slab. Firstly, drastic EZ segmentation changes due to large photoreceptor loss are identified by pixels with abnormally low value in an EZ/Bruch’s membrane thickness map (A). Then, the reflection of the EZ segmentation area is generated with respect to a horizontal line crossing the center of the en face image (B) and the EZ location at the pixels below threshold is substituted by the pixels in its symmetric reflection. Finally, a median filter is applied to ensure a smooth EZ segmentation across the whole scan (C). Representative B-scans are shown before (D) and after EZ smoothing (E). As observed in (D), the directional graph search algorithm can properly segment the areas with partial EZ loss but not the areas with total EZ loss.