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. 2017 Dec 14;171(7):1599–1610.e14. doi: 10.1016/j.cell.2017.11.039

Figure 2.

Figure 2

Nsa1 Module and Formation of the PET

(A) Binding site of the Nsa1 module consisting of Mak16 (red), Nsa1 (orange), Rpf1 (purple), and Rrp1 (dark blue) bound to ES7a (light gray). A back and side view of the particle is shown. Densities for rRNA domains I, II, and VI as well as the 5.8S rRNA are, respectively, colored in light pink, purple, green, and beige. The vertical dashed line through the particle in the upper left view indicates the clipping plane for the cropped density. Loop 4D-5A, suggested to interact with the AAA-ATPase Rix7, is indicated in blue.

(B) Maturation of the PET from states C–F. The N terminus of Rpf1 occupies the tunnel in states A–D; state E shows a free tunnel; and state F displays the C terminus of Nog1 residing in the tunnel.