Figure 2.

Assessing the Ability of Chaperones and Nanobodies to Counteract the Influx of Ca²⁺ Ions Resulting from the Addition of Aliquots of Human CSF

(A and B) Inhibition of the influx of Ca²⁺ ions into individual vesicles caused by AD CSF by clusterin (150 nM) (A) and the nanobody Nb3 (150 nM) (B).

(C and D) Inhibition of the influx of Ca²⁺ ions into astrocytes caused by human CSF of individuals suffering from AD by clusterin (25 nM) (C) and the nanobody Nb3 (150 nM) (D). The statistical data for the experiments are summarized in Tables S1 and S2. Error bars, SEM.