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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Toxicol Lett. 2017 Nov 24;283:100–105. doi: 10.1016/j.toxlet.2017.11.028

Figure 3.

Figure 3

N-acetylation of MOCA (top) and O-acetylation of N-hydroxy-MOCA (bottom) catalyzed by human recombinant NAT2 allozymes. Each bar represents Mean ± SEM for three to five determinations. MOCA N-acetyltransferase activities differed significantly across the allozymes following one way analysis of variance (p<0.0001). NAT2 allozymes 5A, 5B, 5C, 5D, 6A, 6B, 7A, 7B, 14A, and 14B catalyzed MOCA N-acetylation at rates much lower than NAT2 4 reference. N-hydroxy-MOCA O-acetyltransferase activities differed significantly across the allozymes following one way analysis of variance (p<0.0001). NAT2 allozymes 5A, 5B, 5C, 5D, 6A, 6B, 7A, 7B, 13, 14A, and 14B catalyzed N-hydroxy- MOCA O-acetylation at rates much lower than NAT2 4 reference. Rates of MOCA N-acetylation and N-hydroxy-MOCA O-acetylation were highly correlated following linear regression. (r2) = 0.931; p<0.0001.