Skip to main content
. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Biol Psychiatry. 2017 Jun 27;84(11):817–826. doi: 10.1016/j.biopsych.2017.06.022

Figure 4.

Figure 4

A diurnal rhythm in GLUA1 expression in WT mice is abolished in Clock mutants. (A) The diurnal rhythm of total protein levels of GLUA1 across 6 time points, normalized to GAPDH expression in mutant and WT NAc tissue. A significant curve fit was found in WT but not in mutant data (bars below represent light and dark phases). (B) Rhythmic profile of the GLUA1 S/I ratio in WT and mutant across the light/dark cycle showing a loss of significant rhythm in mutant NAc. (C) Acrophase of diurnal expression rhythms of total GLUA1 and S/I ratio in mutant and WT accumbens. Acrophase measures were derived from the center of gravity of the fitted harmonic curves (+SEM; n = 5–9 mice for all groups).