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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Biol Psychiatry. 2017 Jun 27;84(11):817–826. doi: 10.1016/j.biopsych.2017.06.022

Figure 6.

Figure 6

Functional up-regulation of GluA1 in the NAc of ClockΔ19 mice normalizes exploratory drive behavior and conditioned reward sensitivity during the light phase. (A) Timeline of experimental procedures testing the effect of AAV9-hsyn-GluA1 or AAV9-hsyn-GFP expression on behavior in mutant and WT mice (S – saline; C – cocaine) (B) Representative image of GFP viral expression localized to the NAc. (C) Accumbal GluA1 transcript levels following viral overexpression compared with GFP expression. (D) Locomotor activity in a novel environment of mutant and WT animals. (E) Total time spent in the open arms of the EPM during 10 min of testing. (F) Percent open arm entries in the EPM normalized to total crosses. (G) Cocaine CPP scores of all experimental groups following a biased conditioning paradigm. LV- lateral ventricle; AC – anterior commissure; NAcc – nucleus accumbens core; NAcSh – nucleus accumbens shell.