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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Acta Physiol (Oxf). 2017 Jul 25;222(2):10.1111/apha.12914. doi: 10.1111/apha.12914

Figure 2.

Figure 2

Failed vascular recovery leads to peritubular capillary rarefaction following AKI. Concurrent with resolution of GFR and tubular repair recovery of the capillary endothelium is inefficient due to a combination of EndoMT and low endothelial proliferation. Infiltration of pro-angiogenic hematopoietic cells provide pro-angiogenic stimulation but renal endothelium is unresponsive due to the lack of HPP-ECFC activity intrinsic in kidney. Expansion of fibroblasts or myofibroblasts, which derive from either pericyte activation or EndoMT, may occlude blood vessels leading to a rarefied capillary bed.