Table 1.

Author, reference, year	Cell Type	Biological Source	Model/Biological Effect
Patschan et al100 2006	Pro-angiogenic	Murine spleen and kidney	Unilateral I/R in FVB/NJ and Tie-2-GFP mice
			Reduced plasma creatinine by ~50% post I/R
			No evidence of homing
Patschan et al101 2010	Pro-angiogenic	Murine peripheral blood, spleen and bone marrow	Unilateral I/R in male C57BL/6N mice
			Reduced plasma creatinine by ~40–75% post-I/R
			Reduced plasma creatinine by ~90% post-I/R with Epac-1 Ac pretreatment
			Evidence of minimal homing
Patschan et al121 2012		Murine peripheral blood and spleen	Similar models as above; pretreatment of cells with melatonin, Angiopoietin-1 and BMP-5 enhances protective response, with minimal homing
Patschan et al122 2013
Patschan et al123 2013
Patschan et al124 2015	Pro-angiogenic	Murine peripheral blood and spleen	Bilateral I/R in male C57BL/6N mice, reduced plasma creatinine, increased endothelial autophagy and decreased
Patschan et al442016			EndoMT and attenuated capillary rarefaction
Burger et al1122015	ECFC & ECFC exosomes	Human umbilical cord	Bilateral I/R in male NOD-SCID mice
			Reduced plasma creatinine by ~40% post-I/R
			Improved tubular morphology
			No evidence of homing
Collett et al192017	ECFC	Rat PMVEC and human ECFC-conditioned media	Bilateral I/R in male Sprague Dawley rats
			Reduced plasma creatinine by ~50% post-I/R
			Improved tubular morphology
			Prevented loss of medullary blood flow
			No evidence of homing
Viñas et al91 2016	ECFC	Human umbilical cord blood ECFC derived exosomes	Bilateral I/R in male FVB mice
			Reduced plasma creatinine by ~90% post-I/R
			Improved tubular morphology
Brodsky et al111 2001	EC	Human umbilical cord	Unilateral I/R in male Athymic rats
			Reduced plasma creatinine by ~50% post-I/R
			Maintained microvascular perfusion
			Evidence of minimal homing
Cantaluppi et al115 2012	ECFC derived microvesicles	Human peripheral blood	Unilateral I/R in male Wistar rats
			Reduced plasma creatinine by ~80% post-I/R
			Improved tubular morphology
			Prevented capillary rarefaction
Liang et al125 2015	EC	Human Umbilical cords (Wharton’s Jelly)	Unilateral I/R in male C57BL/6 mice
			Reduced plasma creatinine by ~70% post-I/R
			Improved tubular morphology
			Potential prevention of capillary rarefaction
			Evidence of minimal homing
Pang et al113 2017	EC or ECFC	Human renal artery	Bilateral I/R and nephron mass reduction in NOD-SCID mice. Reduced plasma creatinine by ~50% post-I/R
			Prevented capillary rarefaction
			Minimal homing near peritubular capillaries up to 10 days
Patschan et al114 2017	Indeterminate	Murine peripheral blood and spleen	Bilateral I/R in male C57BL/6 mice
			Reduced plasma creatinine by ~10% at 1 week, did not prevent capillary rarefaction
Zullo et al126 2015	Indeterminate	Murine embryonic EPC line cultured with MSCs	Improved renal function, medullary RBF and increased M1 to M2 macrophage polarization in LPS induced endoxemia in C57BL6 mice.

ECFC-endothelial colony forming cells; EC-endothelial cells