Table 1.
Pharmacokinetics properties of oseltamivir phosphate (OP, parent drug) and oseltamivir carboxylate (OC, active metabolite) among pregnant and non-pregnant women.19,31
| Drug and parameter | Non-pregnant | Pregnant |
|---|---|---|
| OP (parent drug) | ||
| Bioavailability | 80% | |
| AUCa (ng/mL/h) | 157 (±54) | 164 (±51) |
| CL/Fb (L/h) | 543 (±225) | 501 (± 160) |
| Vz/Fc (L) | 1768 (±1445) | 2108 (± 1366) |
| T1/2d(h) | 3 (±4.1) | 3.1 (± 2.1) |
| OC (active metabolite) | ||
| AUC (ng/mL/h) | 4719 (± 1263) | 3460 (± 1350) |
| CL/F (L/h) | 17 (± 4.7) | 24.5 (± 8.4) |
| Vz/F (L) | ||
| T1/2 (h) | 7.1 (± 1.9) | 6.2 (± 1.6) |
a
Area under the plasma concentration curve.
b
Apparent oral clearance.
c
Apparent volume of distribution.
d
Apparent half-life.