Table 5.
Studies of SPG block for migraine
| Migraine | ||||||||
|---|---|---|---|---|---|---|---|---|
| Author | Year | Medical problems | Approach | Imaging | Medication | Number of cases | Study design | Outcome |
| Amster et al. [28] | 1948 | Migraine | Cotton tipped applicator, transnasal approach | None | Nupercaine, pontocaine, monocaine | 4 | Case series | Relief of pain and spasm in 90% of cases |
| Maizels et al. [56] | 1999 | Migraine with aura | Self-administered intranasal 4% lidocaine | None | 4% lidocaine | 1 | Case report | Most headaches were successfully aborted for 15 months |
| Yarnitsky et al. [57] | 2003 | Migraine | Cotton tip applicator | None | 2% lidocaine | 32 | Case series | Significant reduction in pain score during migraine |
| Cady et al. [15] | 2015 | Chronic migraine | Tx360 | None | 0.5% bupivacaine | 38 | Double blind, placebo control | Significantly decreased headache at 24 h |
| Cady et al. [16] | 2015 | Chronic migraine | Tx360 | None | 0.5% bupivacaine | 38 | Double blind, placebo control | No statistical difference at 1 month and 6 months between treatment and control groups. |